By bus
Greyhound Bus Lines (http://www.greyhound.com), 1300 West Airport Blvd., Phone: 407-688-9725. Station is open from 8 am to 10 pm, 7 days a week, including holidays. Greyhound offers bus connections to Jacksonville, Orlando, and other cities throughout the U.S.
By plane
You can fly into Orlando-Sanford International Airport IATA: SFB (http://www.orlandosanford...) on Allegiant Air (http://www.allegiantair.com) or Direct Air. Some international flights from Europe mainly the British Isles also use Sanford as an entry point to the United States.
By train
Sanford is the southern terminus of the Amtrak Auto Train which carries passengers and automobiles between Sanford and Lorton, Virginia, effectively serving as a car-rail link from Florida to the Washington, D.C. Metro Area. The Sanford station is not as elaborate as its Lorton counterpart. Passengers currently board the train on two tracks in Sanford; however, Amtrak and the State of Florida are working on plans to replace the older station with a new terminal that can accommodate large numbers of passengers more comfortably. The station is also projected to be a stop on the proposed Central Florida Commuter Rail system.
By car
Sanford is located at the intersection of Interstate 4 and Florida State Road 417.